WebDec 1, 2024 · Recent advances in redoxomics for assessment of the cell glutathionylome have also identified the presence of so-called conformationdependent cryptic cysteines, like in titin (discussed above),... WebMar 1, 2014 · Cryptic cysteines that become exposed under mechanical loads have recently been identified in elastic proteins of the cytoskeleton and the extracellular …
Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic …
WebCryptic Cysteines in Titin The amino acid sequence of the Ig domains in the elastic I-band of titin is highly abundant in cysteine residues, all of which are potential targets for S-glutathionylation (Figure 1B; Kellermayer and Grama, 2002). WebOur Research 1 Cryptic Cysteines, Redox Signaling, & Protein Structure Dynamics We are interested how redox signaling depends on regulation of protein structure and cysteine solvent accessibility. We've shown this specifies redox signaling networks and think it has implications for understanding protein structure dynamics more broadly. chinese food in midtown miami
Cystine Stones: Symptoms, Causes, Treatments
WebJul 21, 2024 · These cysteines were buried and inaccessible in the absence of EGF. These findings indicate that redox regulation of proteins is not solely conditioned upon intracellular redox status, but also upon protein activation status. ... Spatial and temporal alterations in protein structure by EGF regulate cryptic cysteine oxidation. Sci. Signal. 13 ... WebDec 24, 2024 · Crystal structures of arsenic-bound p53 mutants reveal a cryptic allosteric site involving three arsenic-coordinating cysteines within the DNA-binding domain, distal to the zinc-binding site. Arsenic binding stabilizes the DNA-binding loop-sheet-helix motif alongside the overall β-sandwich fold, endowing p53 mutants with thermostability and ... WebNational Center for Biotechnology Information grand lake winter carnival