SpletHere we show that inhibiting PCSK9-a key protein in the regulation of cholesterol metabolism 6-8 -can boost the response of tumours to immune checkpoint therapy, through a mechanism that is independent of PCSK9's cholesterol-regulating functions.

PCSK9 and cancer: Rethinking the link. Semantic Scholar

SpletDespite its great success, cancer immune therapy is still of limited efficacy in the majority of cancer patients 1,2.Many efforts are underway to identify novel approaches to enhance immune checkpoint therapy 3–5.Here we show that inhibition of PCSK9, a key protein in regulating cholesterol metabolism 6–8, can boost tumor response to immune checkpoint … SpletMechanistically, we find that PCSK9 can disrupt the recycling of MHC I to the cell surface by associating with it physically and promoting its relocation and degradation in the … quincy jones bossa nova album

S-palmitoylation of PCSK9 induces sorafenib resistance in liver …

Splet01. avg. 2024 · In a number of studies, PCSK9 siRNA was shown to effectively suppress the proliferation and invasion of the several studied tumor cells. Hence, a novel application of … SpletMore recently, PCSK9 has also been found to regulate cancer development ( Mahboobnia et al., 2024 ). Specifically, PCSK9 promoted cancer cell proliferation and apoptosis inhibition in neuroglioma ( Piao et al., 2015 ), lung adenocarcinoma ( Xu et al., 2024 ), and melanoma ( Sun et al., 2012 ). Splet17. jun. 2024 · In a number of studies, PCSK9 siRNA was shown to effectively suppress the proliferation and invasion of the several studied tumor cells. Hence, a novel application of … quincy jones juke joint