Thioredoxin-like protein
WebThe thioredoxin (Trx) system, which is composed of NADPH, thioredoxin reductase (TrxR), and thioredoxin, is a key antioxidant system in defense against oxidative stress through its disulfide reductase activity regulating protein dithiol/disulfide balance. The Trx system provides the electrons to thiol-dependent peroxidases (peroxiredoxins) to ... WebMar 1, 2024 · The thioredoxin-like protein exists widely, in various organisms, as a regulator of redox homeostasis. In this study, the full-length cDNA of a thioredoxin-like protein gene from rotifer Brachionus plicatilis (designated as BpTXNL) was obtained by 5′ rapid amplification of cDNA end (RACE) technology.The complete cDNA of BpTXNL was 1111 …
Thioredoxin-like protein
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WebFeb 5, 2024 · Txnl1 is the first example of a direct connection between protein reduction and proteolysis, two major intracellular protein quality control mechanisms. Title: Thioredoxin … WebApr 7, 2009 · We found that Arabidopsis AtTDX, a heat-stable and plant-specific thioredoxin (Trx)-like protein, exhibits multiple functions, acting as a disulfide reductase, foldase chaperone, and holdase chaperone. The activity of AtTDX, which contains 3 tetratricopeptide repeat (TPR) domains and a Trx motif, depends on its oligomeric status.
WebAug 31, 2004 · Thioredoxin-like protein CXXS1. Gene. CXXS1. Status. UniProtKB reviewed (Swiss-Prot) Organism. Arabidopsis thaliana (Mouse-ear cress) Amino acids. 118. Protein … WebThe protein disulfide isomerase active site, Trp-Cys-Gly-His-Cys, is present only in the catalytic a domains, while the b domains have thioredoxin-like folding but no sequence homology with the a domains. The b domains have an important role in the specificity of binding to substrate proteins (Freedman et al., 2002). Typical protein disulfide ...
WebThioredoxin is a class of small redox proteins known to be present in all organisms. It plays a role in many important biological processes, ... Thioredoxin is a 12-kD oxidoreductase protein. Thioredoxin proteins also have a characteristic tertiary structure termed the thioredoxin fold. WebPubMed
WebJan 17, 2002 · The 2.0 angstrom AhpD crystal structure reveals a thioredoxin-like active site that is responsive to lipoamide. We propose that Lpd, SucB (the only lipoyl protein detected in Mtb), AhpD, and AhpC together constitute a nicotinamide adenine dinucleotide (reduced)–dependent peroxidase and peroxynitrite reductase.
Thioredoxin is a class of small redox proteins known to be present in all organisms. It plays a role in many important biological processes, including redox signaling. In humans, thioredoxins are encoded by TXN and TXN2 genes. Loss-of-function mutation of either of the two human thioredoxin genes is lethal at … See more They are found in nearly all known organisms and are essential for life in mammals. See more Thioredoxin is a 12-kD oxidoreductase protein. Thioredoxin proteins also have a characteristic tertiary structure termed the thioredoxin fold. The active site contains a dithiols in a CXXC motif. These two cysteines are the key to the ability of thioredoxin to … See more Trx1 has been shown to downregulate cardiac hypertrophy, the thickening of the walls of the lower heart chambers, by interactions with several different targets. Trx1 upregulates the transcriptional activity of nuclear respiratory factors 1 and 2 ( See more • RuBisCO - enzyme activity regulated by thioredoxin • Peroxiredoxin - enzyme activity regulated by thioredoxin • Thioredoxin fold • Thioredoxin reductase See more The primary function of Thioredoxin (Trx) is the reduction of oxidized cysteine residues and the cleavage of disulfide bonds. Multiple in vitro substrates for thioredoxin have been identified, including ribonuclease, choriogonadotropins, coagulation factors, … See more Thioredoxin has been shown to interact with: • ASK1, • Collagen, type I, alpha 1, • Glucocorticoid receptor, See more Thioredoxin is used in skin care products as an antioxidant in conjunction with glutaredoxin and glutathione. See more rgb mj26WebThioredoxin serves as a general protein disulfide oxidoreductase. It interacts with a broad range of proteins by a redox mechanism based on reversible oxidation of 2 cysteine thiol … rgblink tao 1 proWebThioredoxin interacting protein (TXNIP) of the arrestin family is a powerful inhibitor of tumour growth and angiogenesis and suppressor of metastasis. The inhibition of angiogenesis might occur via suppression of Akt-mediated upregulation of vascular endothelial growth factors (VEGFs). TXNIP also inhibits the NF-κB survival pathway and ... rgb mj36